![]() ![]() Basal respiration was altered by PBP ATP-linked respiration by PBP and TBBPA, and maximum respiration by all three FRs. Following 18hr exposure of murine BV-2 cells, at dose levels resulting in ≥80% viability (10 and 40μM), limited alterations in pro-inflammatory responses were observed however, changes were observed in mitochondrial respiration. As representative of the nervous system innate immune system, the current study examined changes in microglia following exposure to representative FRs, pentabromophenol (PBP), tetrabromobisphenol A (2,2’,6,6’,-tetrabromo-4,4’-isopropylidine diphenol TBBPA) and triphenyl phosphate (TPP). In this regard, reports of flame retardant (FR)-related effects on the innate immune system suggest process by which a spectrum of adverse health effects could manifest across the life-span. However, exposure related issues for susceptible populations, the developing, infirmed, or aged, remain given environmental persistence and home-environment detection. ![]() The predominant reliance on bromated flame retardants (BFRs) is diminishing with expanded use of alternative organophosphate flame retardants. ![]()
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